Based on the video game Volition Deep Silver, Agents of Mayhem: Pride of Babylon is a competitive miniatures game that pits the evil Legion (the League of Evil Gentlemen Intent on Obliterating Nations) against the more heroic, but potentially just as chaotic and destructive Mayhem ( Multinational Agency for Hunting Evil Masterminds).

The game is played on a map with multi-story modular buildings that can be destroyed and modified as the battle rages on. Miniature battles themselves are asymmetrical, as the Legion player controls an entire army of diverse and terrifying robots, dark matter forces, gigantic golems and doomsday devices, while the Mayhem player gets to assemble a team of three elite specialist agents and send them can make unique.

The game features a campaign, where the Mayhem player tracks the progress and upgrades of his agents through a series of missions, while the Legion player deploys more fearsome and dangerous squads of troopers. Choices made, victories and defeats, and buildings and blocks damaged and destroyed during battles will influence later missions and ensure that each campaign plays out differently.